Mouse gene suppresses Alzheimer's plaques and tangles Nov 12, 2009
D., of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University, Stanley Cohen, Ph. D., of the Department of Genetics at Stanford University School of Medicine, Limin Li, Ph. (EurekAlert!)
HIV Tamed By Designer 'Leash' Oct 30, 2009
"Tetherin is essentially a rod with anchors at either end that are critical for its function," says Paul Bieniasz of Howard Hughes Medical Institute and the Aaron Diamond AIDS Research Center at The Rockefeller University. Either one of those anchors gets incorporated into the envelope surrounding HIV or other viruses as they bud through the plasma membrane of an infected cell. (Science Daily)
Cellular Mechanism That Causes Lupus-like Symptoms In Mice Identified Oct 20, 2009
31, 2005) Scientists at The Rockefeller University have determined that the autoimmune disease lupus results from a combination of genetics that likely varies from person to person, and that a common. (Aug. (Science Daily)
Inhibitors Of Important Tuberculosis Survival Mechanism Identified Oct 13, 2009
Now, a team of scientists including researchers from the U.S. Department of Energy s (DOE) Brookhaven National Laboratory, Stony Brook University (SBU), Weill Cornell Medical College, and The Rockefeller University has identified compounds that inhibit that mechanism without damaging human cells. See also. (Science Daily)
New Mathematical Model Suggests How The Brain Might Stay In Balance Oct 5, 2009
Marcelo O. Magnasco, head of the Laboratory of Mathematical Physics at The Rockefeller University, and his colleagues developed the model to address how such a massively complex and responsive network such as the brain can balance the opposing forces of excitation and inhibition. His model s key assumption: Neurons function together in localized groups to preserve stability. (Science Daily)
Transgenic Songbirds Provide New Tool To Understand The Brain Sep 30, 2009
"The roadblock had been that you couldn't manipulate the genes," says Fernando Nottebohm, Dorothea L. Leonhardt Professor and head of the Laboratory of Animal Behavior at The Rockefeller University, where the research was conducted. "Ultimately, you have to understand how things are working at the most basic molecular level, and this will take our research there.". (Science Daily)
57 college presidents declare support for public access to publicly funded research in the US Sep 24, 2009
and Wikipedia, as well as state and local ISPs); the Rockefeller University Press; OXFAM; and major national and regional research organizations. For details, visit. (EurekAlert!)
Six biologists win Nat'l Medal Sep 19, 2009
Another winner, is a developmental cell biologist at The Rockefeller University and a Howard Hugh Medical Institute investigator. Her work focuses on multipotent stem cells of the skin. (The Scientist)
Scientific honor roll includes old genetic rivals Sep 18, 2009
Elaine Fuchs of The Rockefeller University, a biologist specializing in the study of skin stem cells. James Gunn of Princeton University, an astrophysicist known for his work in camera design and the study of galaxy formation. (MSNBC -- Environment)
US Energy Use Drops In 2008 Sep 8, 2009
That is the claim of Jesse Ausubel of the Rockefeller University in New York. He explains that building enough wind farms, damming enough rivers, and growing enough. (Science Daily)
Fresh targets give hope for HIV vaccine Sep 5, 2009
Earlier this year, Mascola and a research team led by Michel Nussenzweig of The Rockefeller University in New York cloned more than 500 HIV-specific antibodies from 6 elite controllers, and showed that up to 50 antibodies contributed to the overall protective effect. "We don t know which result is more common, or if they both happen," Mascola says. (Scientific American)
W.M. Keck Foundation Awards $1 Million to Hutchinson Center Scholar to Study How Cells Go Awry Aug 4, 2009
Shou completed her postdoctoral work in quantitative biology at the Rockefeller University and in computational biology at Memorial Sloan-Ketting Cancer Center. She earned her doctorate from the California Institute of Technology. (PR Newswire)
Short Stressful Events May Improve Working Memory Jul 28, 2009
D., from The Rockefeller University. The research was supported by grants from the National Institutes of Health to Yan and a National Alliance for Research on Schizophrenia and Depression Young Investigator Award to Yuen. (Science Daily)
Songbird Cries For Food Show Vocal Learning Jul 27, 2009
It may have started as cheating, says Fernando Nottebohm, head of the Laboratory of Animal Behavior at The Rockefeller University. By generating a diversity of calls, young birds may trick their parents into losing track of whom they last fed, in effect creating the impression of several individuals. (Science Daily)
Report offers principles for maintaining the integrity and accessibility of research data Jul 23, 2009
The report was sponsored by the National Research Council, U.S. Department of Agriculture, NASA, U.S. Geological Survey, U.S. Department of Health and Human Services, U.S. Department of Energy, Eli Lilly and Co., Burroughs Wellcome Fund, Nature Publishing Group, the Rockefeller University Press, New England Journal of Medicine, American Chemical Society, Federation of American Societies for Experimental Biology, American Association for the Advancement of Science, American Geophysical Union, and... (EurekAlert!)
St. Jude scientists discover a new mechanism controlling neuronal migration Jul 16, 2009
Jude); and Eve-Ellen Govek and Mary Hatten (The Rockefeller University, New York). The research was supported in part by the March of Dimes, the National Institutes of Health, a Cancer Center Support Grant and ALSAC.. (EurekAlert!)
Report identifies early childhood conditions that lead to adult health disparities Jun 3, 2009
"Improving the developmental trajectory of a child by helping the parents and improving the home environment is probably the single most important thing we can do for the health of that child," says co-author Bruce McEwen, Alfred E. Mirsky Professor and head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at The Rockefeller University. "Adverse childhood experience is one of the largest contributors to such chronic health problems as diabetes and obesity, psychiatric... (EurekAlert!)
For Different Species, Different Functions For Embryonic MicroRNAs May 29, 2009
Researchers at The Rockefeller University looked at the role of a family of microRNAs in the African clawed frog embryo and human embryonic stem cells, comparing their findings with earlier ones in fish, and found that although the genes for these microRNAs were identical across the three species, their function was not. The na ve assumption is that if we understand what these microRNAs do in a fish or in the frog, we can extrapolate to humans, says Ali H. Brivanlou, head of the Laboratory of... (Science Daily)
Stretching Your Mouth Affects What You Hear May 29, 2009
Fernando Nottebohm, a neuroscientist at the Rockefeller University who uses songbirds as a model for human speech, believes Ostry s study represents one of the few examples of direct evidence supporting this hypothesis. Ostry, however, cautions that the somatosensory system could modulate speech perception in several ways without involving the motor system. (Scientific American)
New research helps explain how connexin hemichannels are kept closed May 27, 2009
About the Journal of General Physiology Founded in 1918, the Journal of General Physiology (JGP) is published by the Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists. (EurekAlert!)
Secret Meeting of the Rich May 21, 2009
com confirmed each of the attendees' presence at the meeting held at the residence of the Rockefeller University president on the campus of the Manhattan medical school. It lasted about five hours, beginning in mid-afternoon and continuing through dinner, Stonesifer said. (ABC News -- Business)
New Tag Could Enable More Detailed Structural Studies Of Mammalian Proteins May 13, 2009
In work published last month in Nature Chemical Biology, new research at The Rockefeller University reveals a method that could theoretically be adapted to place a fluorescent probe at any position in any protein in a mammalian cell. The new technology could enable single-molecule fluorescent studies in live cells, says Thomas P. Sakmar, head of the Laboratory of Molecular Biology and Biochemistry. (Science Daily)
How Light Fights Psoriasis May 10, 2009
A new clinical trial under way at the Center for Clinical and Translational Science in The Rockefeller University Hospital will literally shine light on the disease in hopes of finding out. Researchers, including Lowes and Clinical Research Nurse Practitioner Patricia Gilleaudeau, have recruited the first of what will be 20 patients who will visit the hospital three times a week for up to four months to receive narrowband ultraviolet light B (UVB) treatment. (Science Daily)
New Sequencing Technique To Prod Medical Benefits From Killer Venom May 6, 2009
Now, in a methodological breakthrough, researchers at The Rockefeller University have devised a method to speed up this distillation process by orders of magnitude, raising the prospect that they will be able to test a great many of these molecules for their medical potential. Odd as it may sound, some of the deadliest natural agents in the world have the potential to become among the most beneficial, because their array of peptide components or toxins has been refined over hundreds of millions... (Science Daily)
Shilatifard and colleagues clarify the enzymatic activity of factors involved in childhood leukemia May 5, 2009
The Shilatifard Lab also has collaborated with Robert Roeder and colleagues at The Rockefeller University on a publication in Cell that sheds new light on the process of communication between histones known as histone crosstalk ... Authors from The Rockefeller University include Jaehoon Kim, Ph. (EurekAlert!)
UH names 2 presidential finalists May 1, 2009
She is a graduate of Vassar College and received her doctorate from The Rockefeller University, both in New York. A second finalist, Robert Jones, is senior vice president for system academic administration for the University of Minnesota in Minneapolis. (Pacific Business News, HI)
Computational Biology Illuminates How Cells Change Gears Apr 28, 2009
7, 2004) Researchers from The Rockefeller University have uncovered specific mechanisms by which cells that are genetically programmed to commit suicide stimulate growth in surrounding cells. The research. (Science Daily)
Neurons That Control Sociability In Worms Apr 19, 2009
New research at The Rockefeller University has dissected the social proclivities of a model worm, identifying a single type of neuron RMG that decides whether these worms will mingle with their fellows or keep to themselves. See also. (Science Daily)
New Nucleotide Could Revolutionize Epigenetics Apr 17, 2009
The work, conducted in Nathaniel Heintz's Laboratory of Molecular Biology at The Rockefeller University, suggests that a new layer of complexity exists between our basic genetic blueprints and the creatures that grow out of them. "This is another mechanism for regulation of gene expression and nuclear structure that no one has had any insight into," says Heintz, who is also a Howard Hughes Medical Institute investigator. (Science Daily)
CSHL-led team identifies key decision-point at which cells with broken DNA repair themselves or die Apr 11, 2009
D., of the Rockefeller University, had recently published a paper in Nature describing a critical component of the DNA damage-repair signaling cascade. The Tonks-Allis collaboration, along with contributions from Seung Jun Kim, Ph. (EurekAlert!)
Dendritic Cell Lineage Defined Apr 6, 2009
Now, in experiments published in Science, researchers at The Rockefeller University have identified these special cells rites of passage: They have shown the developmental point when dendritic cells part ways with closely related immune cells known as monocytes, at least in mice. The findings could have important implications for research on dendritic cell-based vaccines all over the world. (Science Daily)
Head of group does not speak for this publisher Apr 3, 2009
We at the Rockefeller University Press have proved that this is not true ... The Rockefeller University Press is a member of the Association of American Publishers, of which Schroeder is chief executive, but she does not speak for us when it comes to the issue of access to the results of publicly funded research. (Boston Globe -- Editorial)
Key Protein May Lead to Faster Acting Anti-Depression Drugs Mar 24, 2009
NEW YORK, March 23 /PRNewswire-USNewswire/ -- Research conducted by Nobel laureate Paul Greengard, Medical Director of The Michael Stern Parkinson's Research Center at The Rockefeller University, Dr. Jennifer L. Warner-Schmidt in New York and colleagues in Sweden, demonstrated in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to develop anti-depression drugs that begin working within hours or days rather than the weeks or even months required by... (PR Newswire)
New Technology Opens Gateway To Studying HIV-specific Neutralizing Antibodies Mar 22, 2009
D., of The Rockefeller University led the team of 22 co-investigators in this collaboration. The process begins with collecting memory B cells, which produce antibodies, from HIV-infected individuals previously screened for strong neutralizing antibody responses. (Science Daily)
New Protein Identified In Bacterial Arsenal Mar 18, 2009
Now researchers at The Rockefeller University have identified a new class of these coup artists that appear to take over a key process that regulates a wide range of cellular duties, from cell-cycle progression to cell death, even communication between cells. Scientists in C. Erec Stebbins s Laboratory of Structural Microbiology have discovered the crystal structure of virulence factor SspH2, which is deployed by Salmonella, a mean strain of bacteria that can cause food poisoning, typhoid fever... (Science Daily)
Measuring The Strength Needed To Move Chromosomes Mar 18, 2009
Now researchers at The Rockefeller University and colleagues in Japan have devised a contraption sensitive enough to probe and ply these microscopic spindles and have used it to measure for the first time the structure s stiffness and deformability. The findings, published last month in Nature Methods, are the culmination of four and a half years of refinements. (Science Daily)
A natural approach for HIV vaccine Mar 16, 2009
Now, in research to be published March 15 online by Nature, scientists at The Rockefeller University have laid out a new approach. They have identified a diverse team of antibodies in "slow-progressing" HIV patients whose coordinated pack hunting knocks down the virus just as well as their super-antibody cousins fighting solo. (EurekAlert!)
New Monkey Model For HIV Developed With Altered Human Virus Mar 4, 2009
A team of researchers led by Paul Bieniasz and Theodora Hatziioannou at The Rockefeller University showed that two pig-tailed macaques, given a common antiretroviral treatment one week before and one week after being exposed to the newly engineered HIV, had no signs of infection. "We're not saying we can save the world with antiretroviral pills. But this model will allow us to start studying the best way to administer prophylaxis and do other experiments on preventing HIV-1 infection that could... (Science Daily)
Scientists make HIV that can infect monkeys Mar 3, 2009
"If our research is taken further, we hope that one day perhaps in the not-too-distant future, we'll be able to make vaccines that are intended for use in humans and the very same product will be able to be tested in animals before human trials," Paul Bieniasz of the Rockefeller University in New York, one of the researchers, said in a telephone interview. Scientists have struggled to create an AIDS vaccine. (MSNBC -- Health)
Gene Linked To Anxious Behavior In Mice Mar 2, 2009
Researchers at The Rockefeller University report this week that mice missing a particular gene show a big increase in these symptomatic behaviors. The scientists also show how the gene, Lynx2, alters the way brain cells communicate and say a similar process may underlie anxiety disorders in humans. (Science Daily)
Protein Found Linking Stress And Depression Mar 1, 2009
Part of the reason, according to scientists at The Rockefeller University, may have to do with a little-known family of proteins called kainate receptors that has recently been implicated in major depression. New research in rats may help explain one mechanism by which stress reshapes the brain: namely, by ramping up production of a particular part of these proteins. (Science Daily)
Implicit Licenses Clinical Stage Antibody Program From Lilly Feb 25, 2009
Johnson and Johnson, The Scripps Research Institute, The Rockefeller University, and Lilly are parties to a separate agreement with Implicit which will see the payment to them by Implicit of milestones and royalties on IC14 development and commercialisation. About Acute Lung Injury. (PR Newswire)
How to Save New Brain Cells Feb 24, 2009
But in the early part of the decade Elizabeth Gould, then at the Rockefeller University, demonstrated that new cells arise in the adult brain particularly in a region called the hippocampus, which is involved in learning and memory. Similar reports soon followed in species from mice to marmosets, and by 1998 neuroscientists in the U.S. and Sweden had shown that neurogenesis also occurs in humans [see New Nerve Cells for the Adult Brain, by Gerd Kempermann and Fred H. Gage; Scientific American,... (Scientific American)
Dendritic Cells As New Player In Arteries And Heart Valves Feb 21, 2009
But Jaehoon Choi, a postdoctoral associate in Steinman s Laboratory of Cellular Physiology and Immunology at The Rockefeller University, now has proof positive, at least in mice. More importantly, he and colleagues showed that the key immune cells sit just beneath the lining of the aorta and can project their dendrites into the bloodstream to capture foreign materials. (Science Daily)
Another possible Alzheimer's culprit found Feb 19, 2009
"Now, instead of having one dog in the race, there are two, " said Paul Greengard, a professor at the Rockefeller University in New York who won the Nobel Prize in physiology or medicine in 2000 for his work on nerve cell communication. "It's a very exciting paper. It's going to have a major impact on research in the Alzheimer's field.". (San Francisco Chronicle -- Sports)
Statistical Analysis Could Yield New Drug Target For Multiple Sclerosis Feb 18, 2009
In research published this month in BMC Medical Genetics, scientists from The Rockefeller University and colleagues from the University of Oxford in England and the University of British Columbia in Canada report a binding pocket in a previously implicated gene that may be an attractive research prospect as a potential drug target. The analysis by biostatistician Knut M. Wittkowski, of Rockefeller s Center for Clinical and Translational Science, is the most sweeping to date of a database... (Science Daily)
Inflammation In Colon May Get Doused Before Fueling Cancer Development Feb 11, 2009
24, 1997) Three therapies derived from plants will be tested at The Rockefeller University in New York City for their ability to prevent colorectal cancer, which afflicts some 150,000 Americans each. . (Science Daily)
